#CHANGING I DOSER DOSES COMPUTERS PATCH#
The signal was picked up by a patch on the participant’s skin, which sent this information to a smartphone app (for participants) and an online dashboard (for doctors). In this study, participants chose to take tablets of aripiprazole (an antipsychotic used to treat schizophrenia) containing a sensor that sends a signal when the pill has been taken. Is the medication not working or is it not being taken correctly? Technology may help answer this question. If a patient’s prescribed medication is not helping their symptoms, it can be hard for doctors to know why. Patients with schizophrenia often do not take their medication regularly. Keywords: digital medicine system, clinical decision-making, clinical decision support, patient–provider communication, schizophrenia Most HCPs found the dashboard easy to use (74%) and helpful for improving conversations with participants about their treatment plan and progress (78%).Ĭonclusion: This provider dashboard may facilitate discussions with patients about regular medication-taking, which can improve patient outcomes. Participants whose HCPs used the dashboard more and recommended adherence counseling and participant education (n=61) improved significantly more than participants with less dashboard-active HCPs (n=49) in CGI-I mean score (2.9 versus 3.4 ), total PANSS (mean change: − 9.2 versus − 3.1 ), PANSS positive subscale (− 3.2 versus − 1.5 ), PANSS general subscale (− 4.3 versus − 1.2 ), and Marder factor for negative symptoms (− 1.9 versus 0.0 ). HCPs recommended adherence counseling and participant education most often. HCPs most often accessed dashboard data regarding medication ingestion and missed doses.
Results: To ensure sufficient opportunity for AS engagement, 113 participants who completed ≥ 3 months on study were analyzed. After stratifying HCPs by frequency of dashboard checks and resulting treatment decisions, changes from baseline were calculated for Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression (CGI)–Severity of Illness and CGI-Improvement (CGI-I), and Personal and Social Performance (PSP), and compared using Mann–Whitney U-tests and rank-biserial correlation coefficient ( r) effect sizes. HCPs were instructed to check the dashboard regularly, identify features used, and report impact on treatment decisions. Patients and Methods: Participants used AS for 3– 6 months. This post hoc analysis explored how healthcare providers’ (HCPs) usage of a dashboard that provided medication ingestion information impacted treatment decisions and clinical assessments.
#CHANGING I DOSER DOSES COMPUTERS TRIAL#
A phase 3b open-label clinical trial used aripiprazole tablets with sensor (AS includes pills with ingestible event-marker, wearable sensor patches and smartphone application) in adults with schizophrenia. Antipsychotics can reduce relapse rates, but the characteristics of schizophrenia may hinder medication adherence. Purpose: Schizophrenia is a severe, chronic condition accounting for disproportionate healthcare utilization. Jeffrey M Cochran, 1 Hui Fang, 1 John G Sonnenberg, 2, 3 Elan A Cohen, 4 Jean-Pierre Lindenmayer, 5 J Corey Reuteman-Fowler 1ġOtsuka Pharmaceutical Development & Commercialization, Inc, Princeton, NJ, USA 2Uptown Research Institute, Chicago, IL, USA 3Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA 4Hassman Research Institute, Marlton, NJ, USA 5Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, USAĬorrespondence: Jeffrey M Cochran, Otsuka Pharmaceutical Development & Commercialization, Inc, Princeton, NJ, USA, Tel +1 6, Email